| 摘要 |
PROBLEM TO BE SOLVED: To predict the membrane permeability under a condition inhibiting the activity of carboxyesterase, and establish an evaluation system capable of accurately obtaining only a behavior as a prodrug. SOLUTION: This method for predicting gastrointestinal absoption of an ester-containing compound uses a Caco-2 cells pre-treated with a carboxyesterase inhibitor. COPYRIGHT: (C)2007,JPO&INPIT
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