发明名称 |
Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter |
摘要 |
The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the identification of estrogen receptor ligands having this activity. Compounds that inhibit HL promoter activity are useful as leads, or on their own, to develop therapeutics in the prevention of heart disease
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申请公布号 |
US2006252154(A1) |
申请公布日期 |
2006.11.09 |
申请号 |
US20060471781 |
申请日期 |
2006.06.21 |
申请人 |
WYETH |
发明人 |
HARNISH DOUGLAS C.;SCICCHITANO MARSHALL S.;KARATHANASIS SOTIRIOS K.;HSIAO CHU-LAI |
分类号 |
A61K31/56;A61K31/138;C12N9/20;C12N15/86 |
主分类号 |
A61K31/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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