摘要 |
The present invention is directed to methods and kits based, at least in part, on the identification of allele-specific responsiveness or non-responsiveness to glatiramer acetate for the treatment of immune disorders, such as relapsing-remitting multiple sclerosis. The allele-specific responsiveness or non-responsiveness is based on polymorphisms in the following genes, CTSS, MBP, TCRB, CD95, CD86, IL-1R1, CD80, SCYA5, MMP9, MOG, SPP1 and IL-12RB2. |
申请人 |
YEDA RESEARCH AND DEVELOPMENT COMPANY;TEVA PHARMACEUTICAL INDUSTRIES LTD.;RAPPAPORT FACULTY OF MEDICINE AND RESEARCH INSTITUTE |
发明人 |
MILLER, ARIEL;SINGER, CLARA;GOLDSTAUB, DAN;BEN-ASHER, EDNA;BECKMANN, JACQUES;AVIDAN, NILI;GROSSMAN, IRIS;HAYARDENY, LIAT;LANCET, DORON |