| 摘要 |
The invention relates to a process for the preparation of N-[3-(3-cyanopyrazolo[1,5-[alpha]]pyrimidin-7-yl)phenyl)-N-ethylacetamide, having formula I, comprising: reacting N-[3-(3-dimethylamino-acryloyl)-phenyl]-N-ethyl-acetamide with 5-amino- lH-pyrazol-4-carbonitrile in a medium comprising a solution of hydrochloric or hydrobromic acid in a C-Calcohol, or in a C-Caliphatic or cyclic ether, or in a C-Calkoxyalcohol, or in a 5- to 6-membered aromatic heterocyclic solvent, containing 1-2 oxygen atoms, or in mixtures thereof with water. |
