SEQUENCES FOR IDENTIFICATION OF SPOTS OF CANCER MARKERS BETWEEN TRANSFORMATION GROWTH FACTOR ?1(TGF- ?1) AND TGF ?1 RECEPTOR TYPE II AS DIAGNOSTIC BIOMARKERS IN BREAST CANCER

摘要

Huge and up to now unsolved problem exists with identification of reliable molecular biomarkers by means of which detection of microinvasion or micrometastacity in breast cancer. Therewith for prognostication of clinical predispositions with these patients, i.e. selective differentiation of subgroups with high risk than subgroups of low risk, for further progression of illness and quickened mortality. Invention herewith described relies at experimental proof that structurally identify TGF-?1 ligand-receptor II recognition bookmark (Table 1) Table 1 Identification of three polypeptides characteristical for bookmark recognition between Transformation growth factor - ?1 (tgf- ?1) AND tgf ? receptors of type II (T?RII)