PHARMACEUTICAL COMPOSITION COMPRISING GAS-FILLED MICROCAPSULES FOR ULTRASOUND MEDIATED DELIVERY
摘要
Composition comprising gas filled microcapsules and a bioactive agent, useful for an ultrasound-mediated delivery of said bioactive agent. The microcapsules comprise a relatively stiff shell of polymeric or lipid material and have in particular a resistance to a mechanical index of at least 0.15, while the bioactive agent is substantially unbound to the shell of the microcapsules. The composition of the invention is particularly suitable for effectively delivering a genetic material into a cell, upon exposure of the composition to a level of acoustic pressure capable of destroying a portion of the microcapsules and releasing the gas contained therein.
申请公布号
WO2006111490(A1)
申请公布日期
2006.10.26
申请号
WO2006EP61517
申请日期
2006.04.11
申请人
BRACCO RESEARCH SA;BETTINGER, THIERRY;YAN, FENG;MEHIER-HUMBERT, SOPHIE;FRINKING, PETER
发明人
BETTINGER, THIERRY;YAN, FENG;MEHIER-HUMBERT, SOPHIE;FRINKING, PETER