| 摘要 |
A use in a medical device of at least one salt of organic acid(s), and preferably a benzoate or a sorbate, as an antimicrobial agent is disclosed, and in particular for the manufacturing of an antimicrobial coating for a medical device for the prevention of bacterial infection. This is very usefu l in medical devices having a hydrophilic coating, such hydrophilic urinary catheters. It is further preferred that the pH of the hydrophilic coating is controlled to be in the range 4.0 - 8.0, and preferably in the range 5.0 - 6.0. It is also preferred that the pH of the hydrophilic coating is controll ed to be below 7.0. The pH of the hydrophilic coating could be controlled by means of a pH buffer, and preferably a citrate or phosphate buffer. Specifically, the provision of the salt of organic acid in combination with a pH buffer has proven surprisingly efficient for inhibition of bacterial growth, and for prevention of bacterial infections.
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