IN VIVO MODEL FOR PRECLINICAL DRUG DEVELOPMENT

摘要

The invention provides an in vivo model tumour for use in determining the response of a tumour to a drug. Thus, the invention provides a tumour model which is derived from a cell which is capable of producing an imageable tumour when introduced into a non-human animal. The invention provides an in vivo method for assessing an effect of a test compound on the model tumour. Preferred cells used for the tumour model include GIST (gastrointestinal stromal tumour) cells, cells harbouring mutations in c-KIT and/or PDGFRA and particularly FDC-Pl cells. The preferred model is a mouse.