Pyridinylamino-pyrimidine derivatives as protein kinase inhibitors

摘要

The present invention relates to compounds of formula I, or pharmaceutically acceptable salts thereof, wherein: (A) "a" is a single bond and "b" is a double bond; R¹ and R² are each independently as defined below; R¹⁰ is absent; or (B) "a" is a double bond and "b" is a single bond; R¹ is oxygen; R² is as defined below; and R¹⁰ is H or alkyl; X is S, O, NH, or NR⁷; Y is N or CR⁸; one of Z¹, Z², and Z³ is N or N⁺R^a and the remainder are each independently CR⁷; R¹, R², R⁵ and R⁶ are each independently R⁷; R³ and R⁴ are each independently R⁸; each R⁷ is independently H, halogen, NR^bR^c, OR^d or a hydrocarbyl group optionally substituted by one or more R⁹ groups; each R⁸ is independently H or (CH₂)_nR⁹, where n is 0 or 1; each R⁹ is independently selected from H, halogen, NO₂, CN, R^e, NHCOR^f, CF₃, COR^g, NR^hRⁱ, CONR^jR^k, SO₂NR^lR^m, SO₂Rⁿ, OR^p, OCH₂CH₂OR^q, morpholine, piperidine and piperazine; and R^a-q are each independently H or alkyl, wherein said alkyl group is optionally substituted by one or more R⁹ groups; where the compound is other than [4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-pyridin-2-yl-amine and 4-[4-fluorophenyl)-1-(1-methyl-4-piperidinyl)-1H-imidazol-5-yl]-N-4-pyridinyl-2-pyrimidinamine. Further aspects of the invention relate to the use of compounds of formula I in the treatment of proliferative disorders, viral disorders, CNS disorders, strokes, alopecia and/or diabetes.