| 摘要 |
A method for preparing solid dispersion of sparingly water-soluble drug by using the supercritical fluid process is provided to enhance homogenicity of the solid dispersion and improve solubility of sparingly water-soluble drug sufficient to be injected intravenously without non-aqueous solvents. The method for preparing solid dispersion of sparingly water-soluble drug comprises the steps of: (1) dissolving sparingly water-soluble drug, cyclodextrin derivatives and pharmaceutically acceptable additives in organic solvent to prepare the mixed solution; (2) spraying the mixed solution to the supercritical fluid to produce particles containing sparingly water-soluble drug, cyclodextrin derivatives and pharmaceutically acceptable additives; and (3) introducing the additional supercritical fluid into the particles to remove the organic solvent, wherein the sparingly water-soluble drug is paclitaxel, tacrolimus, cyclosporine, rapamycin or itraconazole; and the amount of cyclodextrin derivatives is 0.1 to 100 parts by weight based on 1 part by weight of sparingly water-soluble drug.
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