发明名称 |
ASYMMETRIC PROCESS FOR PREPARING FLORFENICOL, THIAMPHENICOL,CHLORAMPHENICOL, AND OXAZOLINE INTERMEDIATES |
摘要 |
<p>The present invention comprises a process for the asymmetric synthesis of florfenicol, thiamphenicol or chloramphenicol. In an alternative embodiment, the present invention comprises a process for isomerizing of the S,S-isomer of florfenicol to the R,S-isomer (I)] by sequentially treating with: (i) a lower alkylsulfonyl chloride and a tertiary amine base; (ii) sulfuric acid and water, (iii) an alkali metal hydroxide. The present invention further comprises a process for regioselectively opening an epoxide to form a threo-oxazoline.</p> |
申请公布号 |
CA2152089(C) |
申请公布日期 |
2006.10.24 |
申请号 |
CA19932152089 |
申请日期 |
1993.12.15 |
申请人 |
SCHERING CORPORATION |
发明人 |
WU, GUANG-ZHONG;TORMOS, WANDA I. |
分类号 |
C07C317/32;C07D303/08;A61K31/165;C07B53/00;C07C231/02;C07C231/10;C07C233/18;C07C233/25;C07C315/04;C07D263/14;C07D301/19;C07D303/34 |
主分类号 |
C07C317/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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