发明名称 |
Aza-peptide macrocyclic hepatitis C serine protease inhibitors |
摘要 |
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
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申请公布号 |
US7125845(B2) |
申请公布日期 |
2006.10.24 |
申请号 |
US20030613206 |
申请日期 |
2003.07.03 |
申请人 |
ENANTA PHARMACEUTICALS, INC. |
发明人 |
WU FRANK X. H.;NAKAJIMA SUANNE;LU ZHI-HUI;SUN YING;MIAO ZHENWEI;OR YAT SUN;WANG ZHE |
分类号 |
A61K38/00;A61P31/14;C07K5/078 |
主分类号 |
A61K38/00 |
代理机构 |
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地址 |
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