BIOLOGICAL TARGETS FOR THE DIAGNOSIS, TREATMENT AND PREVENTION OF CANCER

摘要

The present invention relates to methods for detecting, diagnosing, monitoring and prognosing cancer by detecting differences in the expression of one or more, or any combination of the following genes: SLC12A2, FLJ23375, GRM5, TAS2R1, NRXN2, C14orfl60, MGC15668, MGC33486, TMEM16F, FAT, KIAA0195, LRFN, NFASC, BAT2D1, MGC2963, KIAA0685, EDG3, GGTL3, PLVAP, FLJ31528, FLJ90709, VEZATIN, TMPRSS9, ATP13A5, PKHDlLl, C2orfl8, ANKRD22, FAM62B, LOC57168, CDKALl, SLC39A3vl, SLC39A3v2, BAT5, TM9SF4, DC2, VAPB, XTP3TPB, TACSTD2, FNDC3A, GKOOl, OCIAD2, PRO1855, C20orf3, SDFRl, FLJ20481, LENG4, FLJ12443, ARP5 Long, ARP5 Short, TMD0645, NGEP, ILlRAPl, PLXNBl, ATP2B2, FLJl 1848, ENTPD2, PPMlH, KRTKAP3, KCNC3, TM9SF1, ULBPl, C19orf26, KIAA830, KIAA1244, KIAA1797, MGC26856, NETO2, SUSD2, FOLR2, EMR2, ENTPDl, ATPlOB, PTK7, FLJ14681, C20orf22, FLJ14281, FAM8A1, TMED7, C20orfl08, ATADl, GPR154, C14orf27, OSAP, FAD104, FLJ90492, SLC27A3, RON, ATP13A1, DKFZP564D166, ESSPL, EXTL3, KAIl, KIAA0960, MTRNL, SLC27A1, GRIA4, 0R4M1, KIAA1679 or UPK-Ib. The present invention also relates to methods for screening and identifying compounds that modulate the expression of one or more, or any combination of such genes. The invention further relates to the use of such compounds in the prevention, treatment, management and amelioration of cancer. The methods of the invention also comprise the administration of an effective amount of one or more therapies that modulate the expression and/or activity of one or more cancer targets disclosed herein for the prevention, treatment, management and amelioration of cancer.