PHARMACEUTICAL COMPOSITION AND METHOD USING ANTIFUNGAL AGENTIN COMBINATION

摘要

A pharmaceutical composition containing one or more antifungal agents select ed from an arylamidine derivative represented by the general formula: [Chemical Formula 1] (wherein R1 represents an amidino group that may be substituted with a hydroxyl group that may be protected with an acyl group, an amidino group that may be substituted with an alkoxy group that may be substituted, or an amidino group that may be substituted with an aralkyloxy group that may b e substituted; R2 and R3 identically or differently represent a hydrogen atom or a halogen atom) or a salt thereof, an azole antifungal agent, a polyene antifungal agent, a candin antifungal agent and a fluoropyrimidine antifunga l agent has a strong antifungal activity and is useful for the treatment of fungal infection. A method for using them in combination is useful as an excellent therapeutic method for fungal infection. A pharmaceutical composition containing the arylamidine derivative represented by the above general formula or a salt thereof and an immunosuppressing agent has a stron g antifungal activity and is useful for the treatment of fungal infection and a skin disease such as atopic dermatitis. A method for using them in combinati on is useful as an excellent therapeutic method for fungal infection and a skin disease such asatopic dermatitis.