Heterocyclic compounds

摘要

This invention features a compound of formula (I): R₁ is aryl or heteroaryl; each of R₂ and R₄, independently, is H, halogen, CN, alkyl, OR^a, or NR^aR^b; R₃ is H, halogen, CN, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, OR^a, OC(O)R^a, OC(O)NR^aR^b, NR^aR^b, NR^aC(O)R^b, NR^aS(O)R^b, NR^aS(O)₂R^b, NR^aC(O)NR^bR^c, NR^aC(S)NR^bR^c, NR^aC(NR^b)NR^cR^d, NR^aC(O)OR^b, S(O)NR^aR^b, S(O)₂NR^aR^b, S(O)R^a, S(O)₂R^a, C(O)R^a, C(O)OR^a, or C(O)NR^aR^b; R₅ is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; A is O, S, S(O), S(O)₂, or NR^e; B is N or CR^f; X is O, S, S(O), S(O)₂, NR^e, or C(O); Y is a covalent bond, C(O), C-NR^a, O, S, S(O), S(O)₂, or NR^e; Z is N or CH; each of U and V, independently, is N or CR; and W is O, S, or NR^e; in which each of R^a, R^b, R^c, and R^d, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl; R^e is H, alkyl, aryl, acyl, or sufonyl; and R^f is H, alkyl, aryl, acyl, sulfonyl, alkoxyl, amino, ester, amide, CN, or halogen. The compound is useful for treating an interleukin-12 overproduction-related disorder.