发明名称 INHIBITORS OF .ALPHA.4 MEDIATED CELL ADHESION
摘要 The present invention relates to a pharmaceutical composition comprising as an active ingredient a compound of formula (I), wherein Ring A is an aromatic or a heterocyclic ring; Q is a bond, carbonyl, lower alkylene, lower alkenylene, -O-(lower alkylene)-, etc.; n is 0, 1 or 2; Z is oxygen or sulfur, W is oxygen, sulfur, -CH-CH-, -NH- or -N-CH-; R 1, R2 and R3 are the same or different and are hydrogen, halogen, hydroxyl, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkoxy group, a substituted or unsubstituted amino group, etc.; R4 is tetrazolyl, carboxyl group, amide or ester; R5 is hydrogen, nitro, amino, hydroxyl; lower alkanoyl, lower alkyl, etc.; R6 is selected from (a) a substituted or unsubstituted phenyl group, (b) a substituted or unsubstituted pyridyl group, (c) a substituted or unsubstituted thienyl group, (d) a substituted or unsubstitut ed benzofuranyl group, etc.; or a pharmaceutically acceptable salt thereof.
申请公布号 CA2318527(C) 申请公布日期 2006.10.17
申请号 CA19992318527 申请日期 1999.01.19
申请人 TANABE SEIYAKU CO., LTD. 发明人 SIRCAR, ILA;GUDMUNDSSON, KRISTJAN S.;MARTIN, RICHARD
分类号 C07C233/87;C07D295/02;A61K31/198;A61K31/223;A61K31/245;A61K31/27;A61K31/275;A61K31/277;A61K31/33;A61K31/34;A61K31/343;A61K31/352;A61K31/353;A61K31/381;A61K31/40;A61K31/415;A61K31/42;A61K31/426;A61K31/438;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4418;A61K31/445;A61K31/4453;A61K31/495;A61K31/496;A61K31/4965;A61K31/505;A61K31/5375;A61K31/5377;A61K31/54;A61P1/00;A61P3/10;A61P11/06;A61P29/00;A61P43/00;C07C31/44;C07C233/51;C07C235/52;C07C235/58;C07C235/84;C07C237/30;C07C237/32;C07C237/36;C07C237/42;C07C239/14;C07C251/40;C07C255/16;C07C255/57;C07C255/60;C07C271/28;C07C275/36;C07C275/42;C07C275/54;C07C311/08;C07C311/09;C07C311/16;C07C311/21;C07C311/29;C07C311/46;C07C311/51;C07C317/44;C07C317/50;C07C323/63;C07C335/22;C07D207/08;C07D207/26;C07D207/27;C07D207/32;C07D207/325;C07D207/327;C07D207/33;C07D207/333;C07D207/337;C07D207/34;C07D207/40;C07D207/404;C07D211/22;C07D213/26;C07D213/30;C07D213/54;C07D213/56;C07D213/74;C07D213/81;C07D213/82;C07D231/12;C07D233/02;C07D233/72;C07D239/52;C07D241/12;C07D241/24;C07D257/02;C07D257/04;C07D261/08;C07D265/30;C07D277/18;C07D277/20;C07D277/22;C07D277/24;C07D277/30;C07D295/12;C07D295/13;C07D295/14;C07D295/155;C07D295/18;C07D295/185;C07D295/192;C07D307/79;C07D307/80;C07D307/81;C07D311/04;C07D311/58;C07D317/60;C07D319/18;C07D333/12;C07D333/16;C07D333/22;C07D333/24;C07D333/32;C07D333/34;C07D333/36;C07D333/38;C07D491/10;C07D491/113 主分类号 C07C233/87
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