PROCESS FOR PRODUCTION OF REGULATORY T CELL

摘要

A process for producing a regulatory T cell comprising culturing a peripheral CD25⁺CD4⁺ T cell having naive phenotype to give the regulatory T cell. The CD25⁺CD4⁺ T cell can be cultured under stimulation with an antigen. This process can produce a mammalian regulatory T cell in vitro and can also produce an antigen-specific regulatory T cell. The regulatory T cell produced by this process can be used as an immunomodulator for the prevention and treatment of the rejection of organ transplantation, an allergic disease, an autoimmune disease, a graft versus host disease (GVHD), sterility or the like.