| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for efficiently producing a low-molecular weight hyaluronic acid. SOLUTION: The method involves carrying out malt/organic acid fermentation in a state of a raw material hyaluronic acid containing a mineral. Concretely, the mineral is added to the raw material hyaluronic acid having about 500,000-1,200,000 molecular weight, and the resultant mixture is sterilized by steaming with a prescribed amount of purified water. One or mixture of two or more kinds of Aspergillus oryzae, yeast, citric acid bacteria, lactic bacteria, acetic acid bacteria, and the Aspergillus oryzae or the like containing a fiber-splitting enzyme is added to the sterilized mixture and fermented. One or a mixture of two or more kinds of organic acids having carboxy groups such as citric acid, lactic acid, tartaric acid and malic acid is added to the fermented hyaluronic acid, and the resultant mixture is matured by holding the mixture at a prescribed temperature. The resultant product hyaluronic acid is filtered and extracted. The low-molecular weight hyaluronic acid having about 2,000 molecular weight is efficiently produced by the method. COPYRIGHT: (C)2007,JPO&INPIT
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