PROCESS FOR THE SYNTHESIS OF PEPTIDE AMIDES BY SIDE-CHAIN ATTACHMENT TO A SOLID PHASE

摘要

A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching an α-nitrogen protected Cα-carboxamide amino acid to a solid support by its side chain, removing the α-nitrogen protecting group, assembling a peptide chain on said α-nitrogen and then cleaving the assembled peptide amide from the solid support. Novel amino acid analogues, peptide amides and solid-phase supports are also provided.