| 摘要 |
Heterocyclic derivatives of di-N-substituted piperazine or 1,4 di-substitute d piperidine compounds in accordance with formula (I) (including all isomers salts and solvates), wherein one of Y and Z is -N- an d the other is -N- or -CH-; X is -O-, -S-, -SO-, -SO2- or -CH2-; Q is (1), (2), (3); R is alkyl, cycloalkyl, optionally substituted aryl or heteroaryl; R1, R2 and R3 are H or alkyl; R4 is alkyl, cyclolalkyl or (4); R5 is H, alkyl, -C(O)alkyl, arylcarbonyl, -SO2alkyl, ary l- sulfonyl-C(O)Oalkyl, aryloxycarbonyl, -C(O)NH-alkyl or aryl-aminocarbonyl, wherein the aryl portion is optionally substituted; R6 i s H or alkyl; and R7 is H, alkyl, hydroxyalkyl or alkoxyalkyl; are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of treatment are also disclosed.
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