摘要 |
Provided are a polysuccinimide-based polymer which is excellent in the size control of polymer particles, biodegradability and contrast effect, and a contrast agent containing the polysuccinimide-based polymer. The polysuccinimide-based polymer is represented by the formula 1, wherein R1 is a hydrophilic group having a molecular weight of 100-20,000 derived from D-lysine, L-lysine, D,L-lysine, polylysine, polyethylene glycol, poly(vinyl pyrrolidone), dextran, polyethylene oxide or poly(vinyl alcohol); and R2 is a chelating group where a contrast agent selected from gadolinium, manganese, iron oxide, aluminum, silicon, barium, yttrium and rare earth elements is trapped.
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申请人 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY |
发明人 |
CHO, SUN HANG;LEE, HAE BANG;KHANG, GIL SON;LIM, NAK HYUN;LEE, HA YOUNG;JEE, HYE WON;SEO, JIN A;SEO, SEONG MI;LEE, HYUN SUK |