发明名称 |
METHOD FOR PREPARING 2-CYANO-6-METHOXYBENZTHIAZOLE |
摘要 |
FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: invention relates to the improved method for synthesis of 2-cyano-6-methoxybenthiazole that is a key intermediate compound used in synthesis of luminescent biological systems, in particular, lupiferin. Method involves cyaniding reaction of 2-chloro-6-methoxybenzthiazole wherein acetonecyanohydrine is used as a cyaniding agent that is treated with alkaline metal alcoholate alcoholic solution, benzene is added and azeotropic mixture alcohol-benzene is distilled off followed by addition of dimethylsulfoxide and 2-chloro-6-methoxybenzthiazole. Method allows avoiding contact of workers with highly toxic cyanides and to obtain 2-cyano-6-methoxybenzthiazole with higher yield 50-50.8% as compared with the prototype (40%). ^ EFFECT: improved method of synthesis. ^ 3 ex |
申请公布号 |
RU2284999(C1) |
申请公布日期 |
2006.10.10 |
申请号 |
RU20050120818 |
申请日期 |
2005.07.06 |
申请人 |
FEDERAL'NOE GOSUDARSTVENNOE UNITARNOE PREDPRIJATIE "GOSUDARSTVENNYJ NAUCHNYJ TSENTR "NAUCHNO-ISSLEDOVATEL'SKIJ INSTITUT ORGANICHESKIKH POLUPRODUKTOV I KRASITELEJ" (FGUP "GNTS "NIOPIK") |
发明人 |
TITOVA SVETLANA PAVLOVNA;GORDIEVSKAJA EVGENIJA VASIL'EVNA;GORELIK MIKHAIL VIKTOROVICH;LUK'JANETS EVGENIJ ANTONOVICH |
分类号 |
C07D277/68 |
主分类号 |
C07D277/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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