发明名称 |
EXPRESSION SYSTEM USING MAMMALIAN BETA-ACTIN PROMOTER |
摘要 |
<p>Promoter activities were examined by comparing combinations of promoters and enhancers derived from various genes. A hybrid promoter comprising a combination of a CMV enhancer and a mammalian ²-actin promoter, or the post-transcriptional regulatory region of the genomic sequence Woodchuck Hepatitis Virus (WPRE) and a mammalian ²-actin promoter was found to be stronger than existing promoters. Furthermore, the activities of the ²-actin promoters could be enhanced by coexpressing the oncogene product Ras, which is a transactivator.</p> |
申请公布号 |
EP1707629(A1) |
申请公布日期 |
2006.10.04 |
申请号 |
EP20040819918 |
申请日期 |
2004.12.03 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
TSUNODA, HIROYUKI;HABU, KIYOSHI |
分类号 |
C12N15/85;A01K67/027;C07K14/82;C12N5/06;C12N15/11;C12N15/67;C12P21/02;G06F12/14 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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