发明名称 |
Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
摘要 |
Pharmaceutical compositions suitable for oral administration comprising paclitaxel, a solvent, a surfactant, a substituted cellulosic polymer, and optionally but preferably a P-glycoprotein inhibitor. The composition may further comprise a diglyceride or mixture of diglyceride and monoglyceride. The composition generates a supersaturated paclitaxel microemulsion upon contact with water resulting in improved oral bioavailability of paclitaxel.
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申请公布号 |
US7115565(B2) |
申请公布日期 |
2006.10.03 |
申请号 |
US20020047902 |
申请日期 |
2002.01.14 |
申请人 |
PHARMACIA & UPJOHN COMPANY |
发明人 |
GAO PING;MOROZOWICH WALTER |
分类号 |
A61K9/08;A61K38/00;A01N25/00;A61F13/00;A61K9/107;A61K9/48;A61K31/00;A61K31/122;A61K31/337;A61K31/352;A61K31/365;A61K31/415;A61K31/42;A61K31/444;A61K31/50;A61K31/52;A61K31/522;A61K45/00;A61K47/30;A61K47/32;A61K47/34;A61K47/38;A61P25/04;A61P25/06;A61P29/00;A61P43/00 |
主分类号 |
A61K9/08 |
代理机构 |
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