| 摘要 |
<p>The invention relates to a process for obtaining HMG-CoA reductase inhibitors with a purity higher than 99.6% and preferably higher than 99.7%, to be used as antihypercholesterolemic agents, from a fermentation broth. According to the invention, the process comprises the following stages: - clarifying the mycelium broth and concentrating the clarified broth to a lower volume, - acidifying the concentrate to a pH value in the range of 4.5 to 7.5, followed by extracting the HMG-CoA reductase inhibitor with ethyl acetate, carrying out the lactonization - optionally, - crystallizing the HMG-CoA reductase inhibitor from a water-miscible or water-soluble organic solvent, - crystallizing the HMG-CoA reductase inhibitor from an organic solvent having limited miscibility or solubility with water.</p> |
