摘要 |
Disclosed are compounds of formula (I), wherein: R1 is alkyl, alkyl-Ar or Ar, R2 is H, alkyl, alkyl-Ar', NR4, N(CO)R4, alkyl-NR3R4, alkylC(O)NR3R4, alkylC(O)Ar', alkyl-NHC(O)NR3R4, alkylNHC(O)Ar' or alkylSO2R4, Ar is optionally substituted phenyl, furyl, or thienyl, Ar' is optionally substituted phenyl, naphthyl, furyl, pyridyl, thienyl, thiazolyl, isothiazolyl, pyrazolyl, triazolyl, tetrazolyl, imidazolyl, imidazolidinyl, benzofuranyl, indolyl, thiazolidinyl, isoxazolyl, oxadiazolyl, thiadiazolyl, pyrrolyl, or pyrimidyl, A is N(CHO)OH, X is NH, Y is C(O). The compounds are used for the manufacture of medicaments for treating bacterial infections.
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申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
AUBART, KELLY M;BHAT, AJITA;CHRISTENSEN, SIEGFRIED B;LEBER, JACK DALE;LIAO, XIANGMIN |