A PROCESS FOR THE PREPARATION OF 6-O-METHYL ERYTHROMYCIN A DERIVATIVE

摘要

The present invention relates to an improved process for the preparation of 6-O-methylerythromycin A derivatives, intermediates of clarithromycin, by selective methylation of erythromycin A derivative in a mixture of a acyclic or cyclic alkanes having C₆-C₁₀ carbon atoms, and a polar aprotic solvent using a methylating agent in the presence of a base under mild conditions.