The invention encompasses GLP-1 compounds containing a GLP-1 peptide or a GLP-1 peptide with an extended C-terminus that is modified with a reactive group that is capable of forming covalent bonds with a blood component to form a conjugate. The conjugates may be formed in vivo or ex vivo. Methods of treating a subject in need of GLP-1 receptor stimulation using these GLP-1 compounds are also disclosed.
申请公布号
WO03103572(A3)
申请公布日期
2006.09.28
申请号
WO2003US15395
申请日期
2003.06.02
申请人
ELI LILLY AND COMPANY;DIMARCHI, RICHARD, DENNIS;SMILEY, DAVID, LEE;ZHANG, LIANSHAN