发明名称 |
Itpase gene polymorphisms associated with adverse drug reactions to azathioprine |
摘要 |
<p>The present invention provides methods for predicting a patient's risk of an adverse drug reaction to a thiopurine drug such as AZA or 6-MP by genotyping the patient for a polymorphism in the gene encoding ITPase (ITPA). The present invention also provides methods for predicting a patient's risk of an adverse drug reaction to a thiopurine drug by determining a level of ITPase activity or ITP in a sample from the patient. The present invention further provides methods for optimizing therapeutic efficacy in a patient receiving a thiopurine drug by determining whether the patient should be given an alternative drug based on the presence or absence of a polymorphism in the ITPA gene.</p> |
申请公布号 |
GB0616215(D0) |
申请公布日期 |
2006.09.27 |
申请号 |
GB20060016215 |
申请日期 |
2005.02.18 |
申请人 |
GUY'S AND ST THOMAS NHS FOUNDATION TRUST |
发明人 |
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分类号 |
A61K31/522;A61K31/7076;C12Q1/68 |
主分类号 |
A61K31/522 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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