Methods of producing a carbohydrate HIV vaccine or immunogenic composition are provided. One method comprises expressing a glycoprotein with a modified glycosylation, which facilitates binding of the glycoprotein to the 2Gl 2 antibody. Another method comprises iteratively selecting cells with a high affinity for the 2Gl 2 antibody.
申请公布号
WO2006099592(A2)
申请公布日期
2006.09.21
申请号
WO2006US09838
申请日期
2006.03.16
申请人
UNITED THERAPEUTICS CORPORATION;DWEK, RAYMOND, A.;RUDD, PAULINE, M.;RITCHIE, GAYLE;SCANLAN, CHRISTOPHER;CRISPIN, M., D., MAX
发明人
DWEK, RAYMOND, A.;RUDD, PAULINE, M.;RITCHIE, GAYLE;SCANLAN, CHRISTOPHER;CRISPIN, M., D., MAX
