STABILIZED APTAMERS TO PSMA AND THEIR USE AS PROSTATE CANCER THERAPEUTICS

摘要

The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX method with 2'-O-methyl substituted nucleic acids, and cell surface SELEX are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.