CLONING OF THE RETINOIC ACID INDUCIBLE GENE-1 PROMOTER AND USES THEREOF

摘要

The present invention relates to the human Retinoic Acid Inducible Gene-1 (hereafter, "RIG-1") promoter. The present invention provides for the promoter itself which is inducible by interferon, virus infection, retinoic acid and double-stranded RNA. A further embodiment includes expression constructs comprising the RIG-1 promoter operatively linked to a gene of interest, which may be a reporter gene or a therapeutic gene. It also provides for cells and non-human transgenic animals comprising such expression constructs. In addition, the present invention provides for methods of screening agents for anti-viral activity using RIG-1 promoter activation or inhibition as the basis of the screening system.