发明名称 |
NEW POLYMORPHOUS FORMS OF RIFAXIMIN, PROCESSES FOR THEIR PRODUCTION AND USE THEREOF IN MEDICINAL PREPARATIONS |
摘要 |
Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin ´ and rifaximin µ useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention. |
申请公布号 |
KR20060096242(A) |
申请公布日期 |
2006.09.11 |
申请号 |
KR20050068982 |
申请日期 |
2005.07.28 |
申请人 |
ALFA WASSERMANN S.P.A. |
发明人 |
VISCOMI GIUSEPPE CLAUDIO;CAMPANA MANUELA;CONFORTINI DONATELLA;BARBANTI MARIA MIRIAM;BRAGA DARIO |
分类号 |
A61K31/44;C07D499/64 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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