СПОСОБ ПОЛУЧЕНИЯ 4-[1-(ТОЛИЛ-4-СУЛЬФОНИЛ)-1H-ИНДОЛИЛ-2]-БУТ-3-ЕН-2-ОНОВ

摘要

FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: invention relates to a method for synthesis of novel compounds of formulas (Ia-g): wherein: (a) R means -OCH3; R1 means phenyl (Ph); (b) R means -OCH3; R1 means 4-bromophenyl (4-Br-Ph); (c) R means -OCH3; R1 means CH3; (d) R means -OCH3; R1 means 4-CH3-Ph; (e) R means -OCH3; R1 means C2H5; (f) R means -OCH3; R1 means hydrogen atom (H); (g) R means -O-CH2-CH2-O-; R1 means CH3. Method involves interaction of benzhydrol of formulas (IIa-g): wherein values R and R1 are given above with N-furan-2-yl-methyl-4-methylbenzenesulfonamide of the formula: in acetic acid medium in boiling for 0.2-20 h in the presence of phosphoric acid as a catalyst wherein 3 ml of phosphoric acid are added per 0.01 mole of benzhydrol of formulas (IIa-g). Compounds of formulas (Ia-g) can be used in synthesis of novel analogs of anti-tumor preparations. ^ EFFECT: improved method of synthesis, valuable medicinal property of preparations. ^ 2 tbl, 5 ex