PROCESS FOR PRODUCING 2-ACYLTHIOPHENE COMPOUND

摘要

The present invention provides a process for producing a 2-acylthiophene compound which has a low content of the 3-isomer generated as a by-product, the process comprising reacting a thiophene compound represented by formula (1) :
wherein R 1 is a hydrogen atom, a C 1-6 alkyl group, a phenyl group, or a halogen atom, with at least one member selected from the group consisting of acid anhydrides represented by formula (2):
wherein R 2 is a C 1-6 alkyl group or a phenyl group, and
acid halides represented by formula (3):
wherein R 2 is as defined above and X is a halogen atom,
in the presence of a solid acid catalyst at a temperature less than 75°C in the absence of solvent, thus producing a 2-acylthiophene compound represented by formula (4):
wherein R 1 and R 2 are as defined above.