| 摘要 |
Prodrugs of glycogen phosphorylase inhibiting compounds are provided which are useful in treating diabetes, having the formula I <?in-line-formulae description="In-line Formulae" end="lead"?>G(-O<SUB>2</SUB>CR')<SUB>m</SUB>(-OH)<SUB>n</SUB>(-O<SUB>2</SUB>C(CH<SUB>2</SUB>)<SUB>p</SUB>CH<SUB>3</SUB>)<SUB>q</SUB>I<?in-line-formulae description="In-line Formulae" end="tail"?> wherein G is a C<SUB>3 </SUB>to C<SUB>5 </SUB>branched or straight carbon chain and (-O<SUB>2</SUB>CR'), (-OH) and (-O<SUB>2</SUB>C(CH<SUB>2</SUB>)<SUB>p</SUB>CH<SUB>3</SUB>) are attached to any available carbon atom along G; -O<SUB>2</SUB>CR' is a fragment of a compound of formula Ib where W is a bicyclic heteroaryl; m, n, p, q, X, Y, Z, R<SUB>1 </SUB>and R<SUB>2 </SUB>are as defined herein, as exemplified by Further provided are pharmaceutical compositions and methods for treating diabetes and related diseases employing the above compounds above, either alone or in combination with another therapeutic agent.
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