发明名称 |
Method for preparing anti-MIF antibodies |
摘要 |
The specification provides methods of preparing high-affinity antibodies to a macrophage migration inhibitory factor (MIF) in animals in which the MIF gene has been homozygously knocked-out (MIF<SUP>-/-</SUP>). Also provided are methods of preparing hybridomas which produce the anti-MIF antibodies, methods of administering the antibodies to treat inflammatory or cancerous conditions and/or diseases modulated by MIF, as well as compositions comprising said high-affinity anti-MIF antibodies.
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申请公布号 |
US2006191024(A1) |
申请公布日期 |
2006.08.24 |
申请号 |
US20050143737 |
申请日期 |
2005.06.03 |
申请人 |
BIOGEN IDEC, INC. |
发明人 |
KLOETZER WILLIAM S.;HANNA NABIL |
分类号 |
A01K67/027;A01K67/00;A61K39/395;A61P13/12;A61P17/06;A61P19/02;A61P27/02;A61P29/00;A61P31/04;A61P35/00;C07H21/04;C07K14/52;C07K16/24;C12N5/06;C12N15/85;C12P21/02;C12P21/06 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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