| 摘要 |
The present invention relates to kinase polypeptides, nucleotides sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment jof various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the of PTK's and STK's have been identified and their protein structure predicted. <tables id="TABLE-US-00001" num="1"> <table frame="none" colsep="0" rowsep="0" tabstyle="monospace"> <tgroup align="left" colsep="0" rowsep="0" cols="2"> <colspec colname="1" colwidth="217PT" align="left"/> <colspec colname="2" colwidth="0PT" align="left"/> <TBODY VALIGN="TOP"> <ROW> <ENTRY/> </ROW> <ROW> <ENTRY>>SGK177 (SEQ ID NO: 1)</ENTRY> <ENTRY/> </ROW> <ROW> <ENTRY>GCGGAGACGCCCGCTGGCAAGCAGATCCTGCCTCCTTCCCTGGCCAAGGA</ENTRY> </ROW> <ROW> <ENTRY>GCCGCCCCTCCGGGGTAGCTGTGCGCTGGGCGGCGCTCGGACCCCTTGGC</ENTRY> </ROW> <ROW> <ENTRY>AGCCGCAGGTGCCTCCCCAGCCCAGCCCAGCTCAGTCCAGCGCAGCCCAG</ENTRY> </ROW> <ROW> <ENTRY>CCCAGCCCAGCCCGGCGCTCGCAGCCTCCGCCGCTTCCGGGCAGATAGGT</ENTRY> </ROW> <ROW> <ENTRY>GCCTTTTCTTGCTCCTTGCTCTTGGAGTTCTTCTCTTAGTCCCTGTTCCC</ENTRY> </ROW> <ROW> <ENTRY>TGGATGAAAGCATCGCTCCGAGCCTCATGGGAGGAATGAAGGAAGAATCG</ENTRY> </ROW> <ROW> <ENTRY>AGACTAGATATCCAACTAAGGCTTCGGGACATGTTTTGAGCGAAGATGGG</ENTRY> </ROW> <ROW> <ENTRY>TGTTTCTGCCCGGATAGTATAAATCGAGGATCCAGGTCTGGGCAGATTCA</ENTRY> </ROW> <ROW> <ENTRY>ACCATGGGAGCCAACACTTCAAGAAAACCACCAGTGTTTGATGAAAATGA</ENTRY> </ROW> <ROW> <ENTRY>AGATGTCAACTTTGACCACTTTGAAATTTTGCGAGCCATTGGGAAAGGCA</ENTRY> </ROW> <ROW> <ENTRY>GTTTTGGGAAGGTCTGCATTGTACAGAAGAATGATACCAAGAAGATGTAC</ENTRY> </ROW> <ROW> <ENTRY>GCAATGAAGTACATGAATAAACAAAAGTGCGTGGAGCGCAATGAAGTGAG</ENTRY> </ROW> <ROW> <ENTRY>AAATGTCTTCAAGGAACTCCAGATCATGCAGGGTCTGGAGCACCCTTTCC</ENTRY> </ROW> <ROW> <ENTRY>TGGTTAATTTGTGGTATTCCTTCCAAGATGAGGAAGACATGTTCATGGTG</ENTRY> </ROW> <ROW> <ENTRY>GTGGACCTCCTGCTGGGTGGAGACCTGCGTTATCACCTGCAACAGAACGT</ENTRY> </ROW> <ROW> <ENTRY>CCACTTCAAGGAAGAAACAGTGAAGCTCTTCATCTGTGAGCTGGTCATGG</ENTRY> </ROW> <ROW> <ENTRY>CCCTGGACTACCTGCAGAACCAGCGCATCATTCACAGGGATATGAAGCCT</ENTRY> </ROW> <ROW> <ENTRY>GACAATATTTTACTTGACGAACATGGGCACGTGCACATCACAGATTTCAA</ENTRY> </ROW> <ROW> <ENTRY>CATTGCTGCGATGCTGCCCAGGGAGACACAGATTACCACCATGGCTGGCA</ENTRY> </ROW> <ROW> <ENTRY>CCAAGCCTTACATGGCACCTGAGATGTTCAGCTCCAGAAAAGGAGCAGGC</ENTRY> </ROW> <ROW> <ENTRY>TATTCCTTTGCTGTTGACTGGTGGTCCCTGGGAGTGACGGCATATGAACT</ENTRY> </ROW> <ROW> <ENTRY>GCTGAGAGGCCGGAGACCGTATCATATTCGCTCCAGTACTTCCAGCAAGG</ENTRY> </ROW> <ROW> <ENTRY>AAATTGTACACACGTTTGAGACGACTGTTGTAACTTACCCTTCTGCCTGG</ENTRY> </ROW> <ROW> <ENTRY>TCACAGGAAATGGTGTCACTTCTTAAAAAGCTACTCGAACCTAATCCAGA</ENTRY> </ROW> <ROW> <ENTRY>CCAACGATTTTCTCAGTTATCTGATGTCCAGAACTTCCCGTATATGAATG</ENTRY> </ROW> <ROW> <ENTRY>ATATAAACTGGGATGCAGTTTTTCAGAAGAGGCTCATTCCAGGTTTCATT</ENTRY> </ROW> <ROW> <ENTRY>CCTAATAAAGGCAGGCTGAATTGTGATCCTACCTTTGAACTTGAGGAAAT</ENTRY> </ROW> <ROW> <ENTRY>GATTTTGGAGTCCAAACCTCTACATAAGAAAAAAAAGCGTCTGGCAAAGA</ENTRY> </ROW> <ROW> <ENTRY>AGGAGAAGGATATGAGGAAATGCGATTCTTCTCAGACATGTCTTCTTCAA</ENTRY> </ROW> <ROW> <ENTRY>GAGCACCTTGACTCTGTCCAGAAGGAGTTCATAATTTTCAACAGAGAAAA</ENTRY> </ROW> <ROW> <ENTRY>AGTAAACAGGGACTTTAACAAAAGACAACCAAATCTAGCCTTGGAACAAA</ENTRY> </ROW> <ROW> <ENTRY>CCAAAGACCCACAAGGTGAGGATGGTCAGAATAACAACTTGTAA</ENTRY> </ROW> <ROW> <ENTRY> </ENTRY> </ROW> <ROW> <ENTRY>>SGK172 (SEQ ID NO: 2)</ENTRY> </ROW> <ROW> <ENTRY>TCCTCTCCAAACCCATCACCCCTGTCAAGCCATGAGGAAAACATCAGACA</ENTRY> </ROW> <ROW> <ENTRY>AATCCCAGTGGAAGACATTCTACAAAACACCGGATCAGTACAACTCAC</ENTRY> </ROW> <ROW> <ENTRY> </ENTRY> </ROW> <ROW> <ENTRY>>SGK159 (SEQ ID NO: 3)</ENTRY> </ROW> <ROW> <ENTRY>ATGCCCGCCCACTCCCTGGTGGCAGGTGAGGCGGAGCGGGGCGCTCGGCG</ENTRY> </ROW> <ROW> <ENTRY>CGCGGGGCGGGGCGCGCCGGGGGGAAGGGCGCGGGCTGCGCGCGCCGCTA</ENTRY> </ROW> <ROW> <ENTRY>TTGTGTGCGGGGCTCCTCCGCACGGCGAGGCGCGGGCGCTGCTCTCCGCT</ENTRY> </ROW> <ROW> <ENTRY>CCGCCAGGCCGCCGCCAGACTCTGGCCACGGCCCGCGCGCTCCTCGCCTC</ENTRY> </ROW> <ROW> <ENTRY>TCGCTTCCGCACCGCCCCACAGCCCCGCCGCCGCCGTGCCGCCGCCGCCG</ENTRY> </ROW> <ROW> <ENTRY>CCGCCGCCTCCTCGGACGCTAAGCTCAGCCAGCCGGCTCTCGCCGCACTC</ENTRY> </ROW> <ROW> <ENTRY>CCGCCCGGCCCGCACTCTGCGCCGCAGGAAGGGGAGGGCCGGGGGGAGTG</ENTRY> </ROW> <ROW> <ENTRY>CCATAAGCGTCACCGGCACTGCCCAGTCGTCGTGTCAGAGGCCACCATCG</ENTRY> </ROW> <ROW> <ENTRY>TGGGCATCTGCAAGACCAGGCAGATCTGGCCCAACGATGCGGAGGGCACC</ENTRY> </ROW> <ROW> <ENTRY>TTCCATGGAGACGCAGTTTCCTTGAAGTGA</ENTRY> </ROW> <ROW> <ENTRY> </ENTRY> </ROW> <ROW> <ENTRY>>SGK165 (SEQ ID NO: 4)</ENTRY> </ROW> <ROW> <ENTRY>CCCATGGGAAGGTGCTGTTTGGGTATGAAGCGCTGGACTGACAGATCAAG</ENTRY> </ROW> <ROW> <ENTRY>TGGGCTGGCATTTGGTGGGGGCCCGATGCAGGCCCCACAGAGGCTCCCGA</ENTRY> </ROW> <ROW> <ENTRY>GCCCTTTTGGATCTTCCCCGTTTCCAGCCCATTTTCCAGAACAGAACCTC</ENTRY> </ROW> <ROW> <ENTRY>CAAGGCCCCAGGCTTCTCTCCGGGTGGGAGGGTAACACCCTGGCAGCCTG</ENTRY> </ROW> <ROW> <ENTRY>GATTCCATCTCACCAGCCCCGCAGAACACTCTCCCCCATGCCCCCGGGAC</ENTRY> </ROW> <ROW> <ENTRY>TGGGAGCCCCTGGGTTGGGGAGTTCCTCTGCCTGCCACCTCCCTCTCGCC</ENTRY> </ROW> <ROW> <ENTRY>TCCCCATCCCCCCACCCCACTAAGAAATTCCACGGAGGCCGCTTCCTTCC</ENTRY> </ROW> <ROW> <ENTRY>TGCTTTTAGGAAAAAACACTTTGTCTTAAGCTTCCGCTCCTCCGAGAGAC</ENTRY> </ROW> <ROW> <ENTRY>GGGGGATCTCTGTTTCCTCCGATTGCGCTGTCCTGGGGCCT</ENTRY> </ROW> </TBODY> </TGROUP> </TABLE> </TABLES>
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