COMPOUNDS INHIBITING THE AGGREGATION OF SUPEROXIDE DISMUTASE-1
摘要
<p>The invention is directed to methods of inhibiting the rate at which superoxide dismutse-1 (SOD) aggregates using compounds that stabilize SOD dimers. The methods are useful in the study and therapy of amyotrophic lateral sclerosis. The invention also includes assays that can be used to identify compounds that stabilize dimers and SOD molecules that have been modified for use in these assays.</p>
申请公布号
WO2006089221(A2)
申请公布日期
2006.08.24
申请号
WO2006US05833
申请日期
2006.02.17
申请人
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;LANSBURY, PETER;CHOI, ANDREW;RAY, SOUMYA;NOWAK, RICHARD
发明人
LANSBURY, PETER;CHOI, ANDREW;RAY, SOUMYA;NOWAK, RICHARD