METHODS FOR TRATING CANCER USING AN IMPROVED IMMUNOTOXIN
摘要
The present invention provides a modified toxin having an ETA moiety that has the furin site replaced with a cancer-associated protease site. The present invention also provides modified immunotoxins having a ligand that binds to a cancer cell attached to an ETA moiety that has the furin site replaced with a cancer-associated protease site. Also provided are a method of inhibiting or destroying mammalian cancer cells using the immunotoxins of the invention and pharmaceutical compositions for treating human cancer.
申请公布号
WO2006087196(A2)
申请公布日期
2006.08.24
申请号
WO2006EP01421
申请日期
2006.02.16
申请人
UNIVERSITY OF ZUERICH;ZANGEMEISTER-WITTKE, UWE;DI PAOLO, CLAUDIO