NEUROPROTECTIVE AGENTS AND METHODS OF THEIR USE

摘要

This invention is related to a method of controlling neurodegeneration by
increasing CD 147 receptor signalling. Neuroprotection can be achieved using
cyclophilin A or a functional variant, analog or derivative as a ligand for
the CD 147 receptor administered in various means including gene therapy.
Conditions treatable with this method include cerebral ischemia, Alzheimer''s
Disease, Parkinson''s Disease, Motor Neurone Disease and/or neuronal loss due
to trauma and spinal cord damage.