| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a novel factor which is important for regeneration therapy and has a differentiation-suppressive activity to undifferentiated cells, and an effective medicine useful for tissue regeneration and proliferation maintenance of undifferentiated cells using the same. <P>SOLUTION: Human Delta-1 and Serrate-1 peptides which are ligands of a Notch protein controlling the proliferation of cerebral nerve, muscle and blood cell systems to human homologue and have a specific amino acid sequence are produced by genetic recombination of animal cells, and differentiation-suppressive agents for undifferentiated cells and media for cell culture are obtained thereby. <P>COPYRIGHT: (C)2006,JPO&NCIPI |
