发明名称 |
TRYPTOPHAN AS A FUNCTIONAL REPLACEMENT FOR ADP-RIBOSE-ARGININE IN RECOMBINANT PROTEINS |
摘要 |
A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject. |
申请公布号 |
EP1549746(A4) |
申请公布日期 |
2006.08.16 |
申请号 |
EP20030762212 |
申请日期 |
2003.06.27 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;UNIVERSITY OF MASSACHUSETTS |
发明人 |
MOSS, JOEL;STEVENS, LINDA;BOURGEOIS, CHRISTELLE;BORTELL, RITA |
分类号 |
C12N15/09;A61K38/00;A61P31/00;A61P37/04;C07H21/04;C07K1/107;C07K14/47;C12N9/10;C12N15/55;C12P21/02;C12Q1/48 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|