BIOMARKERS FOR THE EFFICACY OF SOMATOSTATIN ANALOGUE TREATMENT

摘要

Gene expression assays were performed using tissues of monkeys treated with the somatostatin analogue pasireotide at sub-therapeutic dose for 14 days. The assays were analyzed to identify the modes of actions of pasireotide with relationships to therapeutic applications. The effects on the growth hormone/IGF-1 and glucagon/insulin axes were reflected in transcript level changes in several organs. The expressed genes are useful as surrogate markers of the biological activity of pasireotide, especially the findings for IGF-2 in the pituitary and kidneys.