BENZIMIDAZOLE DERIVATIVE FOR TREATING ALLERGY-RELATED DISEASE

摘要

A benzimidazole derivative of formula (I) or its salt wherein A is a single bond or a C1-2 alyklene group (this alkylene group may optionally be substituted by a C1-4 alkyl group), R6 is a C1-4 alkyl group (this alkyl group may optionally be substituted by a phenyl group), B is a C2-3 alkylene group (this alkylene group may optionally be substitute d by a C1-4 alkyl group), X is an oxygen atom, a sulfur atom or NR7 (wherein R7 is a nitro group, a cyano group or a C1-4 alkoxy group), each of R1 and R2 which are independent of each other, is a hydrogen atom, a halogen atom, a C1-4 alkyl group or a C1-4 alkoxy group, E is a C1-2 alkylene group (this alkylene group may optionally be substituted by a C1-4 alkyl group), R3 is a phenyl group (this phenyl gro up may optionally be substituted by a halogen atom, a C1-4 alkyl group or a C1-4 alkoxy group), a C1-4 alkoxy group or a benzyloxy grou p, each of R4 and R5 which are independent of each other, is a C1-4 alkyl group (this alkyl group may optionally be substituted by a phen yl group), D is a C1-2 alkylene group (this alkylene group may optionally be substituted by a C1-4 alkyl group), and Ar is a phenyl group (this phenyl group may optionally be substituted by a halogen atom, a C1-4 alkyl group, a C1-4 alkoxy group or a trifluoromethyl group).