| 摘要 |
Compounds of the formulae <?in-line-formulae description="In-line Formulae" end="lead"?>L<img id="PRIVATE-USE-CHARACTER-00001" he="7.20mm" wi="8.47mm" file="US07091186-20060815-Brketopenst.TIF" alt="private use character Brketopenst" img-content="character" img-format="tif" />A<SUB>n</SUB>-Z-X-W<SUB>w</SUB><img id="PRIVATE-USE-CHARACTER-00002" he="6.77mm" wi="8.47mm" file="US07091186-20060815-Brketclosest.TIF" alt="private use character Brketclosest" img-content="character" img-format="tif" />D and B<img id="PRIVATE-USE-CHARACTER-00003" he="7.20mm" wi="8.47mm" file="US07091186-20060815-Brketopenst.TIF" alt="private use character Brketopenst" img-content="character" img-format="tif" />Z-X-W<SUB>w</SUB><img id="PRIVATE-USE-CHARACTER-00004" he="6.77mm" wi="8.47mm" file="US07091186-20060815-Brketclosest.TIF" alt="private use character Brketclosest" img-content="character" img-format="tif" />D<?in-line-formulae description="In-line Formulae" end="tail"?> wherein: D is a drug moiety; L is a ligand; B is a blocking group; A is an optional acyl unit; Z is an amino acid or a peptide residue; X is an aminobenzyl ether self-immolative spacer group; W is an optional second self-immolative group; n is an integer of 0 or 1; and w is an integer of 0 or 1, and compositions of said compounds with pharmaceutically acceptable carrier, diluent and/or excipient, and methods of delivery the drug D via the compounds.
|
