RNAI-MEDIATED INHIBITION OF OCULAR TARGETS

摘要

RNA interference is provided for inhibition of ocular hypertension target mRNA expression for lowering elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Ocular hypertension targets include carbonic anhydrase II, IV, and XII; ß1- and ß2 adrenergic receptors; acetylcholinesterase; Na⁺/K⁺-ATPase; and Na-K-2Cl cotransporter. Ocular hypertension is treated by administering interfering RNAs of the present invention.