发明名称 |
METHOD AND KIT FOR ESTIMATING SIDE EFFECT BY PACLITAXEL THERAPY |
摘要 |
<p>A method is disclosed for predicting the risk of the occurrence of granulocytopenia caused by paclitaxel therapy in a subject. The method of the present invention comprises identifying a genetic polymorphism in a gene isolated from the subject for five SNPs in CYP2C8 gene (IMS-JST111898 (SEQ ID NO: 1), IMS-JST105874 (SEQ ID NO: 2), IMS-JST082397 (SEQ ID NO: 3), IMS-JST071852 (SEQ ID NO: 4) and IMS-JST071853 (SEQ ID NO: 5)) and for five SNPs in BUB1b gene (IMS-JST074538 (SEQ ID NO: 6), IMS-JST079837 (SEQ ID NO: 7), IMS-JST044164 (SEQ ID NO: 8), IMS-JST 063023 (SEQ ID NO: 9) and IMS-JST042569 (SEQ ID NO: 10)). A kit comprising a reagent used in the method of the present invention is also disclosed.</p> |
申请公布号 |
EP1688492(A1) |
申请公布日期 |
2006.08.09 |
申请号 |
EP20040799655 |
申请日期 |
2004.11.05 |
申请人 |
JAPANESE FOUNDATION FOR CANCER RESEARCH |
发明人 |
MIKI, YOSHIO;MATSUURA, MASAAKI;ISOMURA, MINORU;MIYATA, SATOSHI;YOSHIMOTO, MASATAKA;NODA, TETSUO |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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