| 摘要 |
<p>Process for the isolation of 14-hydroxycodeinone from a reaction mixture after completed conversion of thebaine or analogues thereof by oxidation with hydrogen peroxide or peroxy acids, wherein in the process the pH of the reaction mixture is adjusted by the addition of ammonium hydroxide to a value of from 9 to 10 at a temperature of from 0 to 10 °C, the released base of 14-hydroxycodeinone is extracted with an organic solvent, such as dichloromethane, toluene or their mixture with lower alcohols having 3 to 5 carbon atoms, the organic extract is separated and then optionally concentrated, so obtained 14-hydroxycodeinone is extracted with aqueous solution of an organic acid, such as formic acid or acetic acid, the acid aqueous layer containing 14-hydroxycodeinone is separated, the pH of the solution is adjusted by the addition of ammonium hydroxide to a value of from 9 to 10, so obtained 14-hydroxycodeinone is separated, washed with water and a mixture of acetone and water and dried.</p> |
