发明名称 |
Methods and compositions for modulating stem cell growth and differentiation |
摘要 |
Compositions and methods for modulating proliferation and/or lineage commitment of stem cells by modulating the Wnt signalling pathways. Modulators of the Wnt signalling pathways and screening methods to identify modulators are also provided. The methods of the invention may be conducted in vitro or in vivo to induce or inhibit stem cell proliferation and/or lineage commitment, and are particularly useful for in vivo stimulation of proliferation and/or lineage commitment of resident stem cells in a tissue.
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申请公布号 |
US2006171931(A1) |
申请公布日期 |
2006.08.03 |
申请号 |
US20050318419 |
申请日期 |
2005.12.22 |
申请人 |
RUDNICKI MICHAEL;SEALE PATRICK;POLESSKAYA ANNA;FORTIN ANOUK |
发明人 |
RUDNICKI MICHAEL;SEALE PATRICK;POLESSKAYA ANNA;FORTIN ANOUK |
分类号 |
A61K39/395;A61K35/12;A61K35/34;A61K38/17;C07K14/47;C07K14/475;C12N5/077;G01N33/50 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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